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NADK is activated by oncogenic signaling to sustain pancreatic ductal adenocarcinoma

1 Jun 2021

Abstract excerpt

Metabolic adaptations and the signaling events that control them promote the survival of pancreatic ductal adenocarcinoma (PDAC) at the fibrotic tumor site, overcoming stresses associated with nutrient and oxygen deprivation. Recently, rewiring of NADPH production has been shown to play a key role in this process. NADPH is recycled through reduction of NADP+ by several enzymatic systems in cells. However, de novo...

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PMID: 34133937
DOI: 10.1016/j.celrep.2021.109238

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