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Article

CaV1.2 calcium channel expression in reactive astrocytes is associated with the formation of amyloid-β plaques in an Alzheimer's disease mouse model.

Journal of Alzheimer's disease : JAD - 1 Jan 2013

Daschil Nina, Obermair Gerald J, Flucher Bernhard E, Stefanova Nadia, Hutter-Paier Birgit, Windisch Manfred, Humpel Christian, Marksteiner Josef

Abstract excerpt

Increased activity of L-type Ca2+ channels has been implicated in the pathogenesis of dementia and Alzheimer's disease (AD). Previously we detected CaV1.2 α1-subunit-positive expression in reactive astrocytes surrounding the plaques of 12 month-old transgenic mice overexpressing hAβPP751 with the...

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Share to Amyloid beta-Peptides
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Calcium-Binding Proteins

Share to Calcium Channels, L-Type

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Source

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Identifiers

PMID: 23948887
DOI: 10.3233/JAD-130560
PMCID: PMC4312770

Genes

GFAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23948887-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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