Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

L-type calcium channel CaV 1.2 in transgenic mice overexpressing human AbetaPP751 with the London (V717I) and Swedish (K670M/N671L) mutations.

Journal of Alzheimer's disease : JAD - 1 Jan 2010

Willis Michael, Kaufmann Walter A, Wietzorrek Georg, Hutter-Paier Birgit, Moosmang Sven, Humpel Christian, Hofmann Franz, Windisch Manfred, Knaus Hans-Günther, Marksteiner Josef

Abstract excerpt

Cumulative evidence indicates that amyloid-beta peptides exert some of their neurodegenerative effects through modulation of L-type voltage gated calcium channels, which play key roles in a diverse range of CNS functions. In this study we examined the expression of CaV1.2 L-type voltage gated calcium channels in transgenic mice overexpressing human AbetaPP751 with the London (V717I) and Swedish (K670M/N671L)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Amyloid beta-Protein Precursor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Astrocytes

Share to Calcium Channels, L-Type

Share to Fluorescent Antibody Technique

Share to Mice, Transgenic

Share to Microscopy, Electron

Share to Neurites

Source

Identifiers

PMID: 20413896
DOI: 10.3233/JAD-2010-091117

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

L-type calcium channel CaV 1.2 in transgenic mice overexpressing human AbetaPP751 with the London (V717I) and Swedish (K670M/N671L) mutations.PMID 20413896Read ↗

CaV1.2 calcium channel expression in reactive astrocytes is associated with the formation of amyloid-β plaques in an Alzheimer's disease mouse model.Semantic proximity Read ↗

PS2APP transgenic mice, coexpressing hPS2mut and hAPPswe, show age-related cognitive deficits associated with discrete brain amyloid deposition and inflammation.Semantic proximity Read ↗

Localization and expression of substance P in transgenic mice overexpressing human APP751 with the London (V717I) and Swedish (K670M/N671L) mutations.Semantic proximity Read ↗

Appearance of Amyloid-β Early in Life Initiates Neuronal Hyper-excitability, Mitochondrial Decay, and Loss of Dendritic Complexity in the Hippocampal CA1 Region of 5xFAD MiceSemantic proximity Read ↗

Prominent cerebral amyloid angiopathy in transgenic mice overexpressing the london mutant of human APP in neurons.Semantic proximity Read ↗

Immunohistochemical detection of the delayed formation of nonfibrillar large amyloid-β aggregates.Semantic proximity Read ↗

Enhanced susceptibility of S-100B transgenic mice to neuroinflammation and neuronal dysfunction induced by intracerebroventricular infusion of human beta-amyloid.Semantic proximity Read ↗

Effects of Amyloid-β Peptides on Voltage-Gated L-Type CaV1.2 and CaV1.3 Ca2+ ChannelsSemantic proximity Read ↗

Ca 2+ dysregulation in neurons from transgenic mice expressing mutant presenilin 2Semantic proximity Read ↗

Mutant presenilins disturb neuronal calcium homeostasis in the brain of transgenic mice, decreasing the threshold for excitotoxicity and facilitating long-term potentiation.Semantic proximity Read ↗

Nanoscale CaV channel reorganization links α-synuclein pathology to calcium-dependent transcriptional dysregulationSemantic proximity Read ↗

The Neuropsychiatric Disease-Associated Gene cacna1c Mediates Survival of Young Hippocampal Neurons.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.