Article
Monoclonal antibodies selective for α-synuclein oligomers/protofibrils recognize brain pathology in Lewy body disorders and α-synuclein transgenic mice with the disease-causing A30P mutation.
Journal of neurochemistry - 1 Jul 2013
Fagerqvist Therese, Lindström Veronica, Nordström Eva, Lord Anna, Tucker Stina M E, Su Xingjian, Sahlin Charlotte, Kasrayan Alex, Andersson Jessica, Welander Hedvig, Näsström Thomas, Holmquist Mats, Schell Heinrich, Kahle Philipp J, Kalimo Hannu, Möller Christer, Gellerfors Pär, Lannfelt Lars, Bergström Joakim, Ingelsson Martin
Abstract excerpt
Inclusions of intraneuronal alpha-synuclein (α-synuclein) can be detected in brains of patients with Parkinson's disease and dementia with Lewy bodies. The aggregation of α-synuclein is a central feature of the disease pathogenesis. Among the different α-synuclein species, large oligomers/protofi...
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