Article

A novel reporter allele for monitoring <i>Dll4</i> expression within the embryonic and adult mouse

2017-05-11

Abstract excerpt

Canonical Notch signaling requires the presence of a membrane bound ligand and a corresponding transmembrane Notch receptor. Receptor engagement induces multiple proteolytic cleavage events culminating in the nuclear accumulation of the Notch intracellular domain and its binding to a transcriptional co-factor to mediate gene expression. Notch signaling networks are essential regulators of vascular patterning and a...

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Literature Corpus work: 6e8e3fcf-7c34-5a68-94b0-5eb04a78e978
DOI: 10.1101/136713

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