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Article

Ero1L, a thiol oxidase, is required for Notch signaling through cysteine bridge formation of the Lin12-Notch repeats in Drosophila melanogaster.

The Journal of cell biology - 22 Sept 2008

Tien An-Chi, Rajan Akhila, Schulze Karen L, Ryoo Hyung Don, Acar Melih, Steller Hermann, Bellen Hugo J

Abstract excerpt

Notch-mediated cell-cell communication regulates numerous developmental processes and cell fate decisions. Through a mosaic genetic screen in Drosophila melanogaster, we identified a role in Notch signaling for a conserved thiol oxidase, endoplasmic reticulum (ER) oxidoreductin 1-like (Ero1L). Although Ero1L is reported to play a widespread role in protein folding in yeast, in flies Ero1L mutant clones show...

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Identifiers

PMID: 18809725
DOI: 10.1083/jcb.200805001
PMCID: PMC2542473

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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