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Article

Low-density-lipoprotein-receptor-related protein 1 mediates Notch pathway activation

1 Oct 2021

Abstract excerpt

The Notch signaling pathway controls cell growth, differentiation, and fate decisions, and its dysregulation has been linked to various human genetic disorders and cancers. To comprehensively understand the global organization of the Notch pathway and identify potential drug targets for Notch-related diseases, we established a protein interaction landscape for the human Notch pathway. By combining and analyzing...

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Identifiers

PMID: 34626540
DOI: 10.1016/j.devcel.2021.09.015

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