Article

Phosphorylation of a Cleaved Tau Proteoform at a Single Residue Inhibits Binding to the E3 Ubiquitin Ligase, CHIP

2023-08-16

Abstract excerpt

<h4>ABSTRACT</h4> Microtubule-associated protein tau (MAPT/tau) accumulates in a family of neurodegenerative diseases, including Alzheimer’s disease (AD). In disease, tau is aberrantly modified by post-translational modifications (PTMs), including hyper-phosphorylation. However, it is often unclear which of these PTMs contribute to tau’s accumulation or what mechanisms might be involved. To explore these question...

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Literature Corpus work: c728dfaa-6356-596d-9c32-9c7d3682d275
DOI: 10.1101/2023.08.16.553575

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