Article
Comparison of liver oncogenic potential among human RAS isoforms.
Oncotarget - 9 Feb 2016
Chung Sook In, Moon Hyuk, Ju Hye-Lim, Kim Dae Yeong, Cho Kyung Joo, Ribback Silvia, Dombrowski Frank, Calvisi Diego F, Ro Simon Weonsang
Abstract excerpt
Mutation in one of three RAS genes (i.e., HRAS, KRAS, and NRAS) leading to constitutive activation of RAS signaling pathways is considered a key oncogenic event in human carcinogenesis. Whether activated RAS isoforms possess different oncogenic potentials remains an unresolved question. Here, we compared oncogenic properties among RAS isoforms using liver-specific transgenesis in mice. Hydrodynamic transfection...
Topics
- Animals
- Apoptosis
- Blotting, Western
- Carcinoma, Hepatocellular
- Cell Proliferation
- Cell Transformation, Neoplastic
- Cyclin-Dependent Kinase Inhibitor p16
- GTP Phosphohydrolases
- Gene Expression Regulation, Neoplastic
- Humans
- Immunoenzyme Techniques
- Liver Neoplasms
- Membrane Proteins