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Article

Modeling Hepatitis B Virus X–Induced Hepatocellular Carcinoma in Mice With the Sleeping Beauty Transposon System Δ

24 Nov 2010

Abstract excerpt

UNLABELLED: The mechanisms associated with hepatitis B virus (HBV)-induced hepatocellular carcinoma (HCC) remain elusive, and there are currently no well-established animal models for studying this disease. Using the Sleeping Beauty transposon as a delivery system, we introduced an oncogenic component of HBV, the hepatitis B virus X (HBx) gene, into the livers of fumarylacetoacetate hydrolase (Fah) mutant mice...

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PMID: 21374658
DOI: 10.1002/hep.24091

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