Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differential functions of the KRAS splice variants.

Biochemical Society transactions - 28 Jun 2023

Kochen Rossi Juan, Nuevo-Tapioles Cristina, Philips Mark R

Abstract excerpt

RAS proteins are small GTPases that transduce signals from membrane receptors to signaling pathways that regulate growth and differentiation. Four RAS proteins are encoded by three genes - HRAS, KRAS, NRAS. Among them, KRAS is mutated in human cancer more frequently than any other oncogene. The KRAS pre-mRNA is alternatively spliced to generate two transcripts, KRAS4A and KRAS4B, that encode distinct...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Metabolism, Diabetes, and Cancer
Share to Mutation
Share to Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Isoforms

Share to Protein Kinase Regulation and GTPase Signaling

Share to Proto-Oncogene Proteins p21(ras)

Share to ras Proteins

Share to Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 37222266
DOI: 10.1042/BST20221347
PMCID: PMC10335385

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differential functions of the KRAS splice variants.PMID 37222266Read ↗

A Comparative Analysis of Individual RAS Mutations in Cancer BiologySemantic proximity Read ↗

KRAS Mutations in Cancer: From Molecular Insights to Therapeutic Strategies.Semantic proximity Read ↗

Splice variants of RAS-translational significance.Semantic proximity Read ↗

Classification of KRAS-Activating Mutations and the Implications for Therapeutic Intervention.Semantic proximity Read ↗

Clinical Relevance of KRAS in Human CancersSemantic proximity Read ↗

Gene of the month: KRAS.Semantic proximity Read ↗

KRAS Pathways: A Potential Gateway for Cancer Therapeutics and Diagnostics.Semantic proximity Read ↗

Isoform-specific Ras expression and signallingSemantic proximity Read ↗

Rare codons regulate KRas oncogenesis.Semantic proximity Read ↗

Deciphering the role of KRAS gene in oncogenesis: Focus on signaling pathways, genetic alterations in 3'UTR, KRAS specific miRNAs and therapeutic interventions.Semantic proximity Read ↗

Molecular epidemiology and diagnostics of KRAS mutations in human cancer.Semantic proximity Read ↗

Overlapping and Distinct Functions of an Extended Repertoire of KRAS MutationsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.