Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Liver Injury Increases the Incidence of HCC following AAV Gene Therapy in Mice

23 Oct 2020

Abstract excerpt

Adeno-associated virus (AAV) integrates into host genomes at low frequency, but when integration occurs in oncogenic hotspots it can cause hepatocellular carcinoma (HCC). Given the possibility of recombinant AAV (rAAV) integration leading to HCC, common causes of liver inflammation like non-alcoholic fatty liver disease (NAFLD) may increase the risk of rAAV-induced HCC. A rAAV targeting the oncogenic mouse Rian...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Liver physiology and pathology
Share to Organ Transplantation Techniques and Outcomes
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33554867
DOI: 10.1016/j.ymthe.2020.10.018

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Liver Injury Increases the Incidence of HCC following AAV Gene Therapy in MicePMID 33554867Read ↗

Genetic manipulation using hepatocyte-targeting adeno-associated viral vectors has minimal off-target effectsSemantic proximity Read ↗

Specificity and off-target effects of AAV8-TBG viral vectors for the manipulation of hepatocellular gene expression in miceSemantic proximity Read ↗

Single-Cell Transcriptome Analysis of Mouse Liver Cell-Specific Tropism and Transcriptional Dysregulation Following Intravenous Administration of AAVrh.10 VectorsSemantic proximity Read ↗

Blocking necroptosis reduces inflammation and tumor incidence in a mouse model of diet-induced hepatocellular carcinomaSemantic proximity Read ↗

Hepatic loss of AATF attenuates MASH by suppressing AKT–mTORC1 signaling and reprogramming lipid metabolismSemantic proximity Read ↗

Single-cell analysis of non-alcoholic fatty livers identifies a role for the constitutive androstane receptorSemantic proximity Read ↗

Sleeping Beauty Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic TumorsSemantic proximity Read ↗

Activated Interferon Signaling Suppresses Age-Dependent Liver CancerSemantic proximity Read ↗

Activated Interferon Signaling Suppresses Age-Dependent Liver CancerSemantic proximity Read ↗

Utilization of animal models to investigate nonalcoholic steatohepatitis-associated hepatocellular carcinoma.Semantic proximity Read ↗

Adult mouse model of early hepatocellular carcinoma promoted by alcoholic liver disease.Semantic proximity Read ↗

Diet-induced hepatocellular carcinoma in genetically predisposed mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.