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Article

Transforming Growth Factor-β Promotes Liver Tumorigenesis in Mice via Up-regulation of Snail.

Gastroenterology - 1 Nov 2017

Moon Hyuk, Ju Hye-Lim, Chung Sook In, Cho Kyung Joo, Eun Jung Woo, Nam Suk Woo, Han Kwang-Hyub, Calvisi Diego F, Ro Simon Weonsang

Abstract excerpt

BACKGROUND & AIMS: Transforming growth factor beta (TGF-β) suppresses early stages of tumorigenesis, but also contributes to migration and metastasis of cancer cells. A large number of human tumors contain mutations that inactivate its receptors, or downstream proteins such as Smad transcription factors, indicating that the TGF-β signaling pathway prevents tumor growth. We investigated the effects of TGF-β...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptor, Transforming Growth Factor-beta Type II

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Source

Identifiers

PMID: 28734833
DOI: 10.1053/j.gastro.2017.07.014

Genes

SMAD2
SMAD3
SMAD4
SMAD7
MYC
SNAI1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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