Article
SKP2 cooperates with N-Ras or AKT to induce liver tumor development in mice.
Oncotarget - 10 Feb 2015
Delogu Salvatore, Wang Chunmei, Cigliano Antonio, Utpatel Kirsten, Sini Marcella, Longerich Thomas, Waldburger Nina, Breuhahn Kai, Jiang Lijie, Ribback Silvia, Dombrowski Frank, Evert Matthias, Chen Xin, Calvisi Diego F
Abstract excerpt
Mounting evidence indicates that S-Phase Kinase-Associated Protein 2 (SKP2) is overexpressed in human hepatocellular carcinoma (HCC). However, the role of SKP2 in hepatocarcinogenesis remains poorly delineated. To elucidate the function(s) of SKP2 in HCC, we stably overexpressed the SKP2 gene in the mouse liver, either alone or in combination with activated forms of N-Ras (N-RasV12), AKT1 (myr-AKT1), or β-catenin...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.