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Article

Urea amidolyase (DUR1,2) contributes to virulence and kidney pathogenesis of Candida albicans.

PloS one - 1 Jan 2012

Navarathna Dhammika H M L P, Lionakis Michail S, Lizak Martin J, Munasinghe Jeeva, Nickerson Kenneth W, Roberts David D

Abstract excerpt

The intracellular enzyme urea amidolyase (Dur1,2p) enables C. albicans to utilize urea as a sole nitrogen source. Because deletion of the DUR1,2 gene reduces survival of C. albicans co-cultured with a murine macrophage cell line, we investigated the role of Dur1,2p in pathogenesis using a mouse model of disseminated candidiasis. A dur1,2Δ/dur1,2Δ strain was significantly less virulent than the wild-type strain,...

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Identifiers

PMID: 23144764
DOI: 10.1371/journal.pone.0048475
PMCID: PMC3483220

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Source receipt: pubmed, retrieved 7 Sept 2026.

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