Article
CX3CR1-dependent renal macrophage survival promotes Candida control and host survival.
The Journal of clinical investigation - 1 Dec 2013
Lionakis Michail S, Swamydas Muthulekha, Fischer Brett G, Plantinga Theo S, Johnson Melissa D, Jaeger Martin, Green Nathaniel M, Masedunskas Andrius, Weigert Roberto, Mikelis Constantinos, Wan Wuzhou, Lee Chyi-Chia Richard, Lim Jean K, Rivollier Aymeric, Yang John C, Laird Greg M, Wheeler Robert T, Alexander Barbara D, Perfect John R, Gao Ji-Liang, Kullberg Bart-Jan, Netea Mihai G, Murphy Philip M
Abstract excerpt
Systemic Candida albicans infection causes high morbidity and mortality and is associated with neutropenia; however, the roles of other innate immune cells in pathogenesis are poorly defined. Here, using a mouse model of systemic candidiasis, we found that resident macrophages accumulated in the kidney, the main target organ of infection, and formed direct contacts with the fungus in vivo mainly within the first...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.