Gene Map of the HLA Region, Graves' Disease and Hashimoto Thyroiditis, and Hematopoietic Stem Cell Transplantation.

doi:10.1016/bs.ai.2015.08.003

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Article

Gene Map of the HLA Region, Graves' Disease and Hashimoto Thyroiditis, and Hematopoietic Stem Cell Transplantation.

Advances in immunology - 1 Jan 2016

Sasazuki Takehiko, Inoko Hidetoshi, Morishima Satoko, Morishima Yasuo

Abstract excerpt

The human leukocyte antigen (HLA) genomic region spanning about 4 Mb is the most gene dense and the polymorphic stretches in the human genome. A total of the 269 loci were identified, including 145 protein coding genes mostly important for immunity and 50 noncoding RNAs (ncRNAs). Biological function of these ncRNAs remains unknown, becoming hot spot in the studies of HLA-associated diseases. The genomic diversity...

Topics

Alleles
Autoantibodies
Chromosome Mapping
Epistasis, Genetic
Genetic Predisposition to Disease
Genetic Variation
Graft vs Host Disease
Graft vs Leukemia Effect
Graves Disease
Haplotypes
Hashimoto Disease
Hematopoietic Stem Cell Transplantation
High-Throughput Nucleotide Sequencing

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Open in PubMed

Identifiers

PMID: 26791860
DOI: 10.1016/bs.ai.2015.08.003

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