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Article

Interleukin 4 modulates microglia homeostasis and attenuates the early slowly progressive phase of amyotrophic lateral sclerosis.

Cell death & disease - 14 Feb 2018

Rossi Chiara, Cusimano Melania, Zambito Martina, Finardi Annamaria, Capotondo Alessia, Garcia-Manteiga Jose Manuel, Comi Giancarlo, Furlan Roberto, Martino Gianvito, Muzio Luca

Abstract excerpt

Microglia activation is a commonly pathological hallmark of neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS), a devastating disorder characterized by a selective motor neurons degeneration. Whether such activation might represent a causal event rather than a secondary epiphenomenon remains elusive. Here, we show that CNS-delivery of IL-4-via a lentiviral-mediated gene therapy strategy-skews...

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PMID: 29445154
DOI: 10.1038/s41419-018-0288-4
PMCID: PMC5833860

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