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Article

Methylglyoxal-derived advanced glycation end products contribute to negative cardiac remodeling and dysfunction post-myocardial infarction.

Basic research in cardiology - 1 Sept 2017

Blackburn Nick J R, Vulesevic Branka, McNeill Brian, Cimenci Cagla Eren, Ahmadi Ali, Gonzalez-Gomez Mayte, Ostojic Aleksandra, Zhong Zhiyuan, Brownlee Michael, Beisswenger Paul J, Milne Ross W, Suuronen Erik J

Abstract excerpt

Advanced glycation end-products (AGEs) have been associated with poorer outcomes after myocardial infarction (MI), and linked with heart failure. Methylglyoxal (MG) is considered the most important AGE precursor, but its role in MI is unknown. In this study, we investigated the involvement of MG-derived AGEs (MG-AGEs) in MI using transgenic mice that over-express the MG-metabolizing enzyme glyoxalase-1 (GLO1). MI...

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Identifiers

PMID: 28864889
DOI: 10.1007/s00395-017-0646-x

Genes

GLO1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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