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Article

ASGR1 deficiency improves atherosclerosis but alters liver metabolism in ApoE-/- mice.

Cardiovascular diabetology - 30 Nov 2024

Svecla Monika, Moregola Annalisa, Dalt Lorenzo Da, Nour Jasmine, Baragetti Andrea, Uboldi Patrizia, Idini Alessandra, Wuhrer Manfred, Beretta Giangiacomo, Falck David, Bonacina Fabrizia, Norata Giuseppe Danilo

Abstract excerpt

The asialoglycoprotein receptor 1 (ASGR1), a multivalent carbohydrate-binding receptor that primarily is responsible for recognizing and eliminating circulating glycoproteins with exposed galactose (Gal) or N-acetylgalactosamine (GalNAc) as terminal glycan residues, has been implicated in modulating the lipid metabolism and reducing cardiovascular disease burden. In this study, we investigated the impact of ASGR1...

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Identifiers

PMID: 39616371
DOI: 10.1186/s12933-024-02507-5
PMCID: PMC11608471

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