Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Single-cell and chromatin accessibility profiling reveals regulatory programs of pathogenic Th2 cells in allergic asthma

15 Mar 2025

Abstract excerpt

Lung pathogenic T helper type 2 (pTh2) cells are important in mediating allergic asthma, but fundamental questions remain regarding their heterogeneity and epigenetic regulation. Here we investigate immune regulation in allergic asthma by single-cell RNA sequencing in mice challenged with house dust mite, in the presence and absence of histone deacetylase 1 (HDAC1) function. Our analyses indicate two distinct...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asthma and respiratory diseases
Share to IL-33, ST2, and ILC Pathways
Share to Immune Cell Function and Interaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40089475
DOI: 10.1038/s41467-025-57590-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single-cell and chromatin accessibility profiling reveals regulatory programs of pathogenic Th2 cells in allergic asthmaPMID 40089475Read ↗

Single-cell profiling uncovers regulatory programs of pathogenic Th2 cells in allergic asthmaSemantic proximity Read ↗

Allergen-responsive T helper type 2 cells revealed by high-dimensional profiling in allergen challenged human airwaysSemantic proximity Read ↗

Single-Cell Analysis: A Method for In-Depth Phenotyping of Cells Involved in Asthma.Semantic proximity Read ↗

The chromatin landscape of Th17 cells reveals mechanisms of diversification of regulatory and pro-inflammatory statesSemantic proximity Read ↗

Single-Cell RNA Sequencing of the T Helper Cell Response to House Dust Mites Defines a Distinct Gene Expression Signature in Airway Th2 CellsSemantic proximity Read ↗

Characterizing cellular heterogeneity in fibrotic hypersensitivity pneumonitis by single-cell transcriptional analysisSemantic proximity Read ↗

Th2 Cells in Health and DiseaseSemantic proximity Read ↗

Tertiary lymphoid structures support the development of allergen-specific progenitor CD4+ T cellsSemantic proximity Read ↗

Single-cell RNA sequencing unraveled the expression heterogeneity of hematopoietic stem and progenitor cells and lymphoid cell development dysregulation in childhood asthmaSemantic proximity Read ↗

Single-cell transcriptomic analysis reveals the immune landscape of lung in steroid-resistant asthma exacerbationSemantic proximity Read ↗

T Follicular Helper Cell Plasticity Shapes Pathogenic T Helper 2 Cell-Mediated Immunity to Inhaled House Dust MiteSemantic proximity Read ↗

A phenotypically and functionally distinct human TH2 cell subpopulation is associated with allergic disorders.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.