Article
A phenotypically and functionally distinct human TH2 cell subpopulation is associated with allergic disorders.
Science translational medicine - 2 Aug 2017
Wambre Erik, Bajzik Veronique, DeLong Jonathan H, O'Brien Kimberly, Nguyen Quynh-Anh, Speake Cate, Gersuk Vivian H, DeBerg Hannah A, Whalen Elizabeth, Ni Chester, Farrington Mary, Jeong David, Robinson David, Linsley Peter S, Vickery Brian P, Kwok William W
Abstract excerpt
Allergen-specific type 2 helper T (TH2) cells play a central role in initiating and orchestrating the allergic and asthmatic inflammatory response pathways. One major factor limiting the use of such atopic disease-causing T cells as both therapeutic targets and clinically useful biomarkers is the lack of an accepted methodology to identify and differentiate these cells from overall nonpathogenic TH2 cell types....
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