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Article

TRIM24-Mediated Acetylation of STAT6 Suppresses Th2-Induced Allergic Rhinitis

1 Jan 2023

Abstract excerpt

Purpose: Allergic rhinitis (AR) is a T helper type 2 (Th2)-mediated inflammatory disease.The E3 ligase tripartite motif-containing 24 (TRIM24) regulates the recruitment of acetyltransferase CREB-binding protein (CBP) to signal transducer and activator of transcription 6 (STAT6).CBP mediates the acetylation of STAT6 and decreases its activity.To date, the precise role of TRIM24 in AR has not been fully...

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PMID: 37827979
DOI: 10.4168/aair.2023.15.5.603

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