Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

No sex difference in overall P-glycoprotein activity as assessed by talinolol disposition in humans.

International journal of clinical pharmacology and therapeutics - 1 Mar 2016

Long Bo, Su Yuan-Qi, Xia Ying, Zou Yan-Ye, Tang Bo, Chen Zhong-Jie, Lin Yu

Abstract excerpt

PURPOSE: The aim of this study was to investigate the sex-dependent difference in P-glycoprotein activity as measured by the probe drug talinolol. METHODS: A randomized, single-blind, parallel study was carried out in 20 healthy male and 20 healthy female volunteers. The pharmacokinetics of talinolol were measured after single oral dosing of 50-mg tablet and the pharmacokinetic parameters for male and female...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Area Under Curve
Share to ATP Binding Cassette Transporter, Subfamily B, Member 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genotype

Share to Polymorphism, Genetic

Share to Propanolamines

Share to Sex Characteristics

Share to Single-Blind Method

Source

Identifiers

PMID: 26784939
DOI: 10.5414/CP202477

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

No sex difference in overall P-glycoprotein activity as assessed by talinolol disposition in humans.PMID 26784939Read ↗

Pharmacogenomics, pharmacokinetics and pharmacodynamics: interaction with biological differences between men and womenSemantic proximity Read ↗

Insights into Intestinal P-glycoprotein Function using Talinolol: A PBPK Modeling ApproachSemantic proximity Read ↗

Low heritability in pharmacokinetics of talinolol: a pharmacogenetic twin study on the heritability of the pharmacokinetics of talinolol, a putative probe drug of MDR1 and other membrane transporters.Semantic proximity Read ↗

Effect of quercetin on P-glycoprotein transport ability in Chinese healthy subjects.Semantic proximity Read ↗

Unexpected lack of effect of the rifampin-induced P-glycoprotein on the oral bioavailability of its substrate, talinolol, in humans: implication in phenotyping.Semantic proximity Read ↗

The role of the efflux transporter, P‐glycoprotein, at the blood–brain barrier in drug discoverySemantic proximity Read ↗

MDR1 genotype do not influence the absorption of a single oral dose of 100 mg talinolol in healthy Chinese males.Semantic proximity Read ↗

Pharmacokinetics of tramadol and its three main metabolites in healthy male and female volunteers.Semantic proximity Read ↗

Variability of intestinal expression of P-glycoprotein in healthy volunteers as described by absorption of talinolol from four bioequivalent tablets.Semantic proximity Read ↗

Clinical pharmacokinetic registration file for NDA and ANDA procedures.Semantic proximity Read ↗

Induction of intestinal P-glycoprotein by St John's wort reduces the oral bioavailability of talinolol.Semantic proximity Read ↗

Effects of curcumin on the pharmacokinetics of talinolol in human with ABCB1 polymorphism.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.