Article
Induction of intestinal P-glycoprotein by St John's wort reduces the oral bioavailability of talinolol.
Clinical pharmacology and therapeutics - 1 May 2007
Schwarz U I, Hanso H, Oertel R, Miehlke S, Kuhlisch E, Glaeser H, Hitzl M, Dresser G K, Kim R B, Kirch W
Abstract excerpt
St John's wort (SJW) is known to induce cytochrome P450 (CYP) 3A4 and P-glycoprotein through pregnane X-receptor activation. Our study evaluated the effects of long-term SJW administration on oral and intravenous pharmacokinetics of the nonmetabolized in vivo probe of P-glycoprotein, talinolol, in relation to intestinal P-glycoprotein expression. In a controlled, randomized study (N=9), the pharmacokinetics of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.