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Article

The Length Distribution of Class I-Restricted T Cell Epitopes Is Determined by Both Peptide Supply and MHC Allele-Specific Binding Preference.

Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 2016

Trolle Thomas, McMurtrey Curtis P, Sidney John, Bardet Wilfried, Osborn Sean C, Kaever Thomas, Sette Alessandro, Hildebrand William H, Nielsen Morten, Peters Bjoern

Abstract excerpt

HLA class I-binding predictions are widely used to identify candidate peptide targets of human CD8(+) T cell responses. Many such approaches focus exclusively on a limited range of peptide lengths, typically 9 aa and sometimes 9-10 aa, despite multiple examples of dominant epitopes of other lengths. In this study, we examined whether epitope predictions can be improved by incorporating the natural length...

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Share to CD8-Positive T-Lymphocytes
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Epitopes, T-Lymphocyte

Share to Genes, MHC Class I

Share to HLA-A Antigens

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Source

Open in PubMed Open full text

Identifiers

PMID: 26783342
DOI: 10.4049/jimmunol.1501721
PMCID: PMC4744552

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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