Article
Prediction of MHC-binding peptides of flexible lengths from sequence-derived structural and physicochemical properties.
Molecular immunology - 1 Feb 2007
Cui J, Han L Y, Lin H H, Zhang H L, Tang Z Q, Zheng C J, Cao Z W, Chen Y Z
Abstract excerpt
Peptide binding to MHC is critical for antigen recognition by T-cells. To facilitate vaccine design, computational methods have been developed for predicting MHC-binding peptides, which achieve impressive prediction accuracies of 70-90% for binders and 40-80% for non-binders. These methods have been developed for peptides of fixed lengths, for a limited number of alleles, trained from small number of non-binders,...
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