Article
Genetic heterogeneity of actionable genes between primary and metastatic tumor in lung adenocarcinoma.
BMC cancer - 18 Jan 2016
Kim Eun Young, Cho Eun Na, Park Heae Surng, Kim Arum, Hong Ji Young, Lim Seri, Youn Jong Pil, Hwang Seung Yong, Chang Yoon Soo
Abstract excerpt
BACKGROUND: Biopsy for lung cancer diagnosis is usually done at a single site. But it is unclear that genetic information at one biopsy site represents that of other lesions and is sufficient for therapeutic decision making. METHODS: Non-synonymous mutations and insertions/deletions of 16 genes containing actionable mutations, and intron 2 deletion polymorphism of Bcl2-like11 were analyzed in 41 primary tumor and...
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