Article
Mutational Diversity of Lung Cancer and Associated Lymph Nodes. An Exploratory Prospective Study of 4 Resected cIIIA-N2.
Pathology oncology research : POR - 1 Jan 2019
Legras Antoine, Roussel Hélène, Mangiameli Giuseppe, Arame Alex, Grand Bertrand, Pricopi Ciprian, Badia Alain, Gibault Laure, Badoual Cécile, Fabre Elizabeth, Laurent-Puig Pierre, Blons Hélène, Le Pimpec-Barthes Françoise
Abstract excerpt
Mutational heterogeneity could explain different metastatic patterns among IIIA-N2 lung cancer and influence prognosis. The identification of subclonal mutations using deep sequencing to evaluate the degree of molecular heterogeneity may improve IIIA-N2 classification. The aim of this prospective study was to assess mutational and immunohistochemical characteristics in primary tumours and involved lymph nodes...
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