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Article

Mutational status of synchronous and metachronous tumor samples in patients with metastatic non-small-cell lung cancer.

BMC cancer - 11 Mar 2016

Quéré Gilles, Descourt Renaud, Robinet Gilles, Autret Sandrine, Raguenes Odile, Fercot Brigitte, Alemany Pierre, Uguen Arnaud, Férec Claude, Quintin-Roué Isabelle, Le Gac Gérald

Abstract excerpt

BACKGROUNDS: Despite reported discordance between the mutational status of primary lung cancers and their metastases, metastatic sites are rarely biopsied and targeted therapy is guided by genetic biomarkers detected in the primary tumor. This situation is mostly explained by the apparent stability of EGFR-activating mutations. Given the dramatic increase in the range of candidate drugs and high rates of drug...

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Identifiers

PMID: 26968843
DOI: 10.1186/s12885-016-2249-6
PMCID: PMC4788951

Genes

EGFR
KRAS
ALK
BRAF

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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