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Article

Targeted deep sequencing helps distinguish independent primary tumors from intrapulmonary metastasis for lung cancer diagnosis.

Journal of cancer research and clinical oncology - 1 Sept 2020

Liu Jixian, Mao Guangxian, Li Yingmei, Tao Lili, Wang Weifeng, Peng Xuxing, Wang Junbin, Li Xiaoqiang, Luan Xinyu, Luo Ruixing, Huang Tanxiao, Zhang Jing, Xu Mengmeng, Chen Shifu, Wu Da

Abstract excerpt

PURPOSE: Multiple lung lesions found in a single patient at the time of diagnosis often pose a diagnostic dilemma: are these lesions independent primary tumors (IPT) or the result of intrapulmonary metastases (IPM)? While traditional pathological methods sometimes have difficulty distinguishing IPM from IPT, modern molecular profiling based on next-generation sequencing techniques may provide a new strategy....

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PMID: 32333141
DOI: 10.1007/s00432-020-03227-5

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