Article
Mutation patterns in small cell and non-small cell lung cancer patients suggest a different level of heterogeneity between primary and metastatic tumors.
Carcinogenesis - 1 Feb 2017
Saber Ali, Hiltermann T Jeroen N, Kok Klaas, Terpstra M Martijn, de Lange Kim, Timens Wim, Groen Harry J M, van den Berg Anke
Abstract excerpt
Several studies have shown heterogeneity in lung cancer, with parallel existence of multiple subclones characterized by their own specific mutational landscape. The extent to which minor clones become dominant in distinct metastasis is not clear. The aim of our study was to gain insight in the evolution pattern of lung cancer by investigating genomic heterogeneity between primary tumor and its distant metastases....
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