Article
Influence of XPC, XPD, XPF, and XPG gene polymorphisms on the risk and the outcome of acute myeloid leukemia in a Romanian population.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Jul 2016
Bănescu Claudia, Iancu Mihaela, Trifa Adrian P, Dobreanu Minodora, Moldovan Valeriu G, Duicu Carmen, Tripon Florin, Crauciuc Andrei, Skypnyk Cristina, Bogliș Alina, Lazar Erzsebeth
Abstract excerpt
XPC, XPD, XPF, and XPG genes are implicated in the nucleotide excision repair (NER) system. Gene polymorphisms in NER repair system may influence the individual's capacity to recognize and repair DNA lesions, thus increasing the cancer risk. We hypothesized that these gene polymorphisms might influence the probability of developing acute myeloid leukemia (AML). We investigated the XPC, XPD, XPF, and XPG gene...
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