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Article

XPD gene polymorphisms and the effects of induction chemotherapy in cytogenetically normal de novo acute myeloid leukemia patients.

Hematology (Amsterdam, Netherlands) - 1 Oct 2014

El-Tokhy Mervat A, Hussein Neveen A, Bedewy Ahmed M L, Barakat Mohammad R

Abstract excerpt

BACKGROUND: Cytogenetically normal acute myeloid leukemia (AML) represents nearly half of newly diagnosed de novo AML cases. XPD is one of the DNA repair proteins, whose genetic polymorphisms are thought to affect their function as regards response to chemotherapeutic drugs and chemotherapy-induced toxicities. SUBJECTS AND METHODS: We investigated the XPD Asp312Asn and Lys751Gln polymorphisms by polymerase chain...

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Identifiers

PMID: 24284041
DOI: 10.1179/1607845413Y.0000000144

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