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Article

Distinct functions of the dual leucine zipper kinase depending on its subcellular localization.

Cellular signalling - 1 Apr 2016

Wallbach Manuel, Duque Escobar Jorge, Babaeikelishomi Rohollah, Stahnke Marie-Jeannette, Blume Roland, Schröder Sabine, Kruegel Jenny, Maedler Kathrin, Kluth Oliver, Kehlenbach Ralph H, Miosge Nicolai, Oetjen Elke

Abstract excerpt

The dual leucine zipper kinase DLK induces β-cell apoptosis by inhibiting the transcriptional activity conferred by the β-cell protective transcription factor cAMP response element binding protein CREB. This action might contribute to β-cell loss and ultimately diabetes. Within its kinase domain DLK shares high homology with the mixed lineage kinase (MLK) 3, which is activated by tumor necrosis factor (TNF) α and...

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PMID: 26776303
DOI: 10.1016/j.cellsig.2016.01.002

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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