Article
Regulation of MTK1/MEKK4 kinase activity by its N-terminal autoinhibitory domain and GADD45 binding.
Molecular and cellular biology - 1 Jul 2002
Mita Hiroaki, Tsutsui Junichiro, Takekawa Mutsuhiro, Witten Elizabeth A, Saito Haruo
Abstract excerpt
A variety of cellular stresses activate the stress-responsive mitogen-activated protein (MAP) kinases p38 and JNK. In this study, we studied the activation mechanism of a human MAP kinase kinase kinase, MTK1 (also known as MEKK4), which mediates activation of both p38 and JNK. MTK1 has an extensive N-terminal noncatalytic domain composed of approximately 1,300 amino acids. Full-length or near full-length MTK1 is...
Topics
- Binding Sites
- Calcium-Calmodulin-Dependent Protein Kinases
- Catalytic Domain
- Genetic Complementation Test
- HeLa Cells
- Humans
- Intracellular Signaling Peptides and Proteins
- MAP Kinase Kinase 6
- MAP Kinase Kinase Kinase 4
- MAP Kinase Kinase Kinases
- Mutation
- Peptide Fragments