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Article

Regulation of MTK1/MEKK4 kinase activity by its N-terminal autoinhibitory domain and GADD45 binding.

Molecular and cellular biology - 1 Jul 2002

Mita Hiroaki, Tsutsui Junichiro, Takekawa Mutsuhiro, Witten Elizabeth A, Saito Haruo

Abstract excerpt

A variety of cellular stresses activate the stress-responsive mitogen-activated protein (MAP) kinases p38 and JNK. In this study, we studied the activation mechanism of a human MAP kinase kinase kinase, MTK1 (also known as MEKK4), which mediates activation of both p38 and JNK. MTK1 has an extensive N-terminal noncatalytic domain composed of approximately 1,300 amino acids. Full-length or near full-length MTK1 is...

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Identifiers

PMID: 12052864
DOI: 10.1128/MCB.22.13.4544-4555.2002
PMCID: PMC133894

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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