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Article

Identification of a nuclear localization signal, RRMKWKK, in the homeodomain transcription factor PDX‐1

15 Nov 1999

Abstract excerpt

Pancreatic duodenal homeobox-containing transcription factor 1 (PDX-1) plays a crucial role in pancreas development and beta-cell gene regulation. Absence of PDX-1 leads to pancreas agenesis and its malfunction causes MODY4 diabetes mellitus. PDX-1 has been suggested to be involved in the glucose-dependent regulation of insulin gene transcription. Whereas DNA-binding and transactivation domains of PDX-1 are in...

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PMID: 10567702
DOI: 10.1016/s0014-5793(99)01446-5

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Identification of a nuclear localization signal, RRMKWKK, in the homeodomain transcription factor PDX‐1PMID 10567702Read ↗

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