Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

LMP1 signal transduction differs substantially from TNF receptor 1 signaling in the molecular functions of TRADD and TRAF2.

The EMBO journal - 4 May 1999

Kieser A, Kaiser C, Hammerschmidt W

Abstract excerpt

The Epstein-Barr virus latent membrane protein 1 (LMP1) binds tumor necrosis factor receptor (TNFR)-associated factors (TRAFs) and the TNFR-associated death domain protein (TRADD). Moreover, it induces NF-kappaB and the c-Jun N-terminal kinase 1 (JNK1) pathway. Thus, LMP1 appears to mimick the molecular functions of TNFR1. However, TNFR1 elicits a wide range of cellular responses including apoptosis, whereas LMP1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium-Calmodulin-Dependent Protein Kinases
Share to JNK Mitogen-Activated Protein Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Receptors, Tumor Necrosis Factor

Share to Receptors, Tumor Necrosis Factor, Type I

Share to rho GTP-Binding Proteins

Share to TNF Receptor-Associated Factor 1

Share to TNF Receptor-Associated Factor 2

Share to Viral Matrix Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 10228165
DOI: 10.1093/emboj/18.9.2511
PMCID: PMC1171333

Genes

TRADD
TRAF2
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

LMP1 signal transduction differs substantially from TNF receptor 1 signaling in the molecular functions of TRADD and TRAF2.PMID 10228165Read ↗

The Viral Oncoprotein LMP1 Exploits TRADD for Signaling by Masking Its Apoptotic ActivitySemantic proximity Read ↗

Epstein-Barr virus-transforming protein latent infection membrane protein 1 activates transcription factor NF-kappaB through a pathway that includes the NF-kappaB-inducing kinase and the IkappaB kinases IKKalpha and IKKbeta.Semantic proximity Read ↗

TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB.Semantic proximity Read ↗

A novel dominant-negative mutant form of Epstein-Barr virus latent membrane protein-1 (LMP1) selectively and differentially impairs LMP1 and TNF signaling pathways.Semantic proximity Read ↗

Molecular Mechanisms of TNFR-associated Factor 6 (TRAF6) Utilization by the Oncogenic Viral Mimic of CD40, Latent Membrane Protein 1 (LMP1)Semantic proximity Read ↗

NF-κB and IRF7 Pathway Activation by Epstein-Barr Virus Latent Membrane Protein 1Semantic proximity Read ↗

Epstein-Barr virus-driven B cell lymphoma mediated by a direct LMP1-TRAF6 complexSemantic proximity Read ↗

Multiple carboxyl-terminal regions of the EBV oncoprotein, latent membrane protein 1, cooperatively regulate signaling to B lymphocytes via TNF receptor-associated factor (TRAF)-dependent and TRAF-independent mechanisms.Semantic proximity Read ↗

Characterization of LMP-1's association with TRAF1, TRAF2, and TRAF3Semantic proximity Read ↗

Unique Signaling Properties of CTAR1 in LMP1-Mediated TransformationSemantic proximity Read ↗

TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling.Semantic proximity Read ↗

Roles of the adaptor protein tumor necrosis factor receptor type 1-associated death domain protein (TRADD) in human diseasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.