Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dlk/ZIP kinase-induced apoptosis in human medulloblastoma cells: requirement of the mitochondrial apoptosis pathway.

British journal of cancer - 30 Nov 2001

Kögel D, Reimertz C, Mech P, Poppe M, Frühwald M C, Engemann H, Scheidtmann K H, Prehn J H

Abstract excerpt

Dlk/ZIP kinase is a member of the Death Associated Protein (DAP) kinase family of pro-apoptotic serine/threonine kinases that have been implicated in regulation of apoptosis and tumour suppression. Expression of both Dlk/ZIP kinase and its interaction partner Par-4 is maintained in four medulloblastoma cell lines investigated, whereas three of seven neuroblastoma cell lines have lost expression of Par-4....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Chloromethyl Ketones
Share to bcl-X Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Calcium-Calmodulin-Dependent Protein Kinases

Share to Caspase Inhibitors

Share to Cysteine Proteinase Inhibitors

Share to Cytochrome c Group

Share to Death-Associated Protein Kinases

Share to Medulloblastoma

Source

Open in PubMed Open full text

Identifiers

PMID: 11742505
DOI: 10.1054/bjoc.2001.2158
PMCID: PMC2363987

Genes

DAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dlk/ZIP kinase-induced apoptosis in human medulloblastoma cells: requirement of the mitochondrial apoptosis pathway.PMID 11742505Read ↗

ZIPK: a unique case of murine-specific divergence of a conserved vertebrate gene.Semantic proximity Read ↗

The Death-Associated Protein Kinases: Structure, Function, and BeyondSemantic proximity Read ↗

Identification of a unique core domain of par-4 sufficient for selective apoptosis induction in cancer cells.Semantic proximity Read ↗

ZIP kinase triggers apoptosis from nuclear PML oncogenic domains.Semantic proximity Read ↗

Essential role of mitochondria in apoptosis of cancer cells induced by the marine alkaloid Lamellarin D.Semantic proximity Read ↗

DAPk Protein Family and CancerSemantic proximity Read ↗

Anaplastic lymphoma kinase is a dependence receptor whose proapoptotic functions are activated by caspase cleavage.Semantic proximity Read ↗

Binding of Par-4 to the actin cytoskeleton is essential for Par-4/Dlk-mediated apoptosis.Semantic proximity Read ↗

DAP-kinase participates in TNF-alpha- and Fas-induced apoptosis and its function requires the death domain.Semantic proximity Read ↗

A caspase-8-independent component in TRAIL/Apo-2L-induced cell death in human rhabdomyosarcoma cells.Semantic proximity Read ↗

Death-associated protein kinase phosphorylates ZIP kinase, forming a unique kinase hierarchy to activate its cell death functions.Semantic proximity Read ↗

C-terminal truncation of Dlk/ZIP kinase leads to abrogation of nuclear transport and high apoptotic activity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.