Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hypoxia Signaling in Parkinson’s Disease: There Is Use in Asking “What HIF?”

29 Jul 2021

Abstract excerpt

Hypoxia is a condition characterized by insufficient tissue oxygenation, which results in impaired oxidative energy production. A reduction in cellular oxygen levels induces the stabilization of hypoxia inducible factor α (HIF-1α), master regulator of the molecular response to hypoxia, involved in maintaining cellular homeostasis and driving hypoxic adaptation through the control of gene expression. Due to its...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Cancer, Hypoxia, and Metabolism
Share to Sirtuins and Resveratrol in Medicine

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34439955
DOI: 10.3390/biology10080723

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hypoxia Signaling in Parkinson’s Disease: There Is Use in Asking “What HIF?”PMID 34439955Read ↗

The Role of Oxygen Homeostasis and the HIF-1 Factor in the Development of NeurodegenerationSemantic proximity Read ↗

The Potential Role of Hypoxia-Inducible Factor-1 in the Progression and Therapy of Central Nervous System DiseasesSemantic proximity Read ↗

Hypoxia signaling in human health and diseases: implications and prospects for therapeuticsSemantic proximity Read ↗

Pro-survival Phenotype of HIF-1α: Neuroprotection Through Inflammatory Mechanisms.Semantic proximity Read ↗

Basic Biology of Hypoxic Responses Mediated by the Transcription Factor HIFs and Its Implication for MedicineSemantic proximity Read ↗

Hypoxia and aging: molecular mechanisms, diseases, and therapeutic targetsSemantic proximity Read ↗

Hypoxia regulation of ATP13A2 (PARK9) gene transcriptionSemantic proximity Read ↗

Systematic and comprehensive insights into HIF-1 stabilization under normoxic conditions: implications for cellular adaptation and therapeutic strategies in cancerSemantic proximity Read ↗

Roles of HIF1α- and HIF2α-regulated BNIP3 in hypoxia-induced injury of neuronsSemantic proximity Read ↗

When the Brain Yearns for OxygenSemantic proximity Read ↗

Hypoxia-Inducible Factor 1: Control of Oxygen Homeostasis in Health and DiseaseSemantic proximity Read ↗

Hypoxia-Inducible Factor-1 (HIF-1): A Potential Target for Intervention in Ocular Neovascular DiseasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.