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Article

Genetic screen identified PRMT5 as a neuroprotection target against cerebral ischemia.

eLife - 19 Feb 2024

Wu Haoyang, Lv Peiyuan, Wang Jinyu, Bennett Brian, Wang Jiajia, Li Pishun, Peng Yi, Hu Guang, Lin Jiaji

Abstract excerpt

Epigenetic regulators present novel opportunities for both ischemic stroke research and therapeutic interventions. While previous work has implicated that they may provide neuroprotection by potentially influencing coordinated sets of genes and pathways, most of them remain largely uncharacterized in ischemic conditions. In this study, we used the oxygen-glucose deprivation (OGD) model in the immortalized mouse...

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Identifiers

PMID: 38372724
DOI: 10.7554/eLife.89754
PMCID: PMC10942588

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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