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Article

Fatty Acid Amide Hydrolase Regulates Peripheral B Cell Receptor Revision, Polyreactivity, and B1 Cells in Lupus.

Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 2016

Pathak Simanta, Kumar Kirthi Raman, Kanta Hasna, Carr-Johnson Ferdicia, Han Jie, Bashmakov Anna, Faure Lionel, Ding Huihua, Vanarsa Kamala, Khan Shaheen, Li Quan-Zhen, Chapman Kent, Wakeland Edward K, Mohan Chandra

Abstract excerpt

C57BL/6 mice bearing the Sle2(z) lupus-susceptibility congenic interval on chromosome 4 display high titers of polyclonal autoantibodies with generalized B cell hyperactivity, hallmarks of systemic lupus erythematosus. In B6.Sle2(z)HEL(Ig).sHEL BCR-transgenic mice, Sle2(z) did not breach central tolerance, but it led to heightened expression of endogenous Ig H and L chains in splenic B cells, upregulation of RAG,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26773143
DOI: 10.4049/jimmunol.1500291

Genes

BCR
FAAH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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