Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The lupus susceptibility locus Sle1 breaches peripheral B cell tolerance at the antibody-forming cell and germinal center checkpoints.

Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2009

Vuyyuru Raja, Mohan Chandra, Manser Tim, Rahman Ziaur S M

Abstract excerpt

We have described a line of V(H) knock-in mice termed HKIR in which the transgenic Igh locus partially encodes "dual-reactive" antichromatin and anti-p-azophenylarsonate (Ars) BCRs. HKIR B cells termed canonical, expressing a particular Vkappa L chain, evade central tolerance by down-regulating BCR levels. Canonical HKIR B cells can be recruited into the primary germinal center (GC) and Ab-forming cell (AFC)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibody-Producing Cells
Share to Autoantigens

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to B-Lymphocyte Subsets

Share to Gene Knock-In Techniques

Share to Germinal Center

Share to Immune Tolerance

Share to Lupus Erythematosus, Systemic

Share to Receptors, Antigen, B-Cell

Source

Open in PubMed Open full text

Identifiers

PMID: 19828626
DOI: 10.4049/jimmunol.0804215
PMCID: PMC2879885

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The lupus susceptibility locus Sle1 breaches peripheral B cell tolerance at the antibody-forming cell and germinal center checkpoints.PMID 19828626Read ↗

Editing disease-associated autoantibodies.Semantic proximity Read ↗

A cholinergic checkpoint controls autoantibody selection via somatic hypermutation in lupus germinal centers.Semantic proximity Read ↗

The lupus susceptibility locus Sle1 facilitates the peripheral development and selection of anti-DNA B cells through impaired receptor editing.Semantic proximity Read ↗

The lupus-prone NZM2410/NZW strain-derived Sle1b sublocus alters the germinal center checkpoint in female mice in a B cell-intrinsic manner.Semantic proximity Read ↗

Two Distinct Pathways in Mice Generate Antinuclear Antigen-Reactive B Cell Repertoires.Semantic proximity Read ↗

Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strainsSemantic proximity Read ↗

Molecular Basis of 9G4 B Cell Autoreactivity in Human Systemic Lupus ErythematosusSemantic proximity Read ↗

The major murine systemic lupus erythematosus susceptibility locus Sle1 results in abnormal functions of both B and T cells.Semantic proximity Read ↗

Regulation of B cell tolerance by 129-derived chromosome 1 loci in C57BL/6 mice.Semantic proximity Read ↗

Lupus susceptibility genes may breach tolerance to DNA by impairing receptor editing of nuclear antigen-reactive B cells.Semantic proximity Read ↗

Extrafollicular responses are sufficient to drive initiation of autoimmunity and early disease hallmarks of lupusSemantic proximity Read ↗

The <i>Yaa</i> Locus and IFN-α Fine-Tune Germinal Center B Cell Selection in Murine Systemic Lupus ErythematosusSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.