Article
FINEMAP: efficient variable selection using summary data from genome-wide association studies.
Bioinformatics (Oxford, England) - 15 May 2016
Benner Christian, Spencer Chris C A, Havulinna Aki S, Salomaa Veikko, Ripatti Samuli, Pirinen Matti
Abstract excerpt
MOTIVATION: The goal of fine-mapping in genomic regions associated with complex diseases and traits is to identify causal variants that point to molecular mechanisms behind the associations. Recent fine-mapping methods using summary data from genome-wide association studies rely on exhaustive search through all possible causal configurations, which is computationally expensive. RESULTS: We introduce FINEMAP, a...
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