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Article

Nutritional stress exacerbates hepatic steatosis induced by deletion of the histidine nucleotide-binding (Hint2) mitochondrial protein.

American journal of physiology. Gastrointestinal and liver physiology - 1 Apr 2016

Martin Juliette, Balmer Maria L, Rajendran Saranya, Maurhofer Olivier, Dufour Jean-François, St-Pierre Marie V

Abstract excerpt

The histidine nucleotide-binding protein, Hint2, is a mitochondrial phosphoramidase expressed in liver, brown fat, pancreas, and muscle. The livers of Hint2 knockout (Hint2(-/-)) mice accumulate triglycerides and show a pattern of mitochondrial protein lysine hyperacetylation. The extent and nature of the lysine acetylation changes and the response of Hint2(-/-) mice to nutritional challenges that elicit a...

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PMID: 26767982
DOI: 10.1152/ajpgi.00178.2015

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