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Article

Degradation of PHLPP2 by KCTD17, via a Glucagon-Dependent Pathway, Promotes Hepatic Steatosis.

Gastroenterology - 1 Dec 2017

Kim KyeongJin, Ryu Dongryeol, Dongiovanni Paola, Ozcan Lale, Nayak Shruti, Ueberheide Beatrix, Valenti Luca, Auwerx Johan, Pajvani Utpal B

Abstract excerpt

BACKGROUND & AIMS: Obesity-induced nonalcoholic fatty liver disease (NAFLD) develops, in part, via excess insulin-stimulated hepatic de novo lipogenesis, which increases, paradoxically, in patients with obesity-induced insulin resistance. Pleckstrin homology domain leucine-rich repeat protein phosphatase 2 (PHLPP2) terminates insulin signaling by dephosphorylating Akt; levels of PHLPP2 are reduced in livers from...

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Share to Cyclic AMP-Dependent Protein Kinases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28859855
DOI: 10.1053/j.gastro.2017.08.039
PMCID: PMC5705280

Genes

KCTD17

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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