Article
WT1-dependent sulfatase expression maintains the normal glomerular filtration barrier.
Journal of the American Society of Nephrology : JASN - 1 Jul 2011
Schumacher Valérie A, Schlötzer-Schrehardt Ursula, Karumanchi S Ananth, Shi Xiaofeng, Zaia Joseph, Jeruschke Stefanie, Zhang Dongsheng, Pavenstädt Hermann, Pavenstaedt Hermann, Drenckhan Astrid, Amann Kerstin, Ng Carrie, Hartwig Sunny, Ng Kar-Hui, Ho Jacqueline, Kreidberg Jordan A, Taglienti Mary, Royer-Pokora Brigitte, Ai Xingbin
Abstract excerpt
Paracrine signaling between podocytes and glomerular endothelial cells through vascular endothelial growth factor A (VEGFA) maintains a functional glomerular filtration barrier. Heparan sulfate proteoglycans (HSPGs), located on the cell surface or in the extracellular matrix, bind signaling molecules such as VEGFA and affect their local concentrations, but whether modulation of these moieties promotes normal...
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