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Article

Chi hotspots trigger a conformational change in the helicase-like domain of AddAB to activate homologous recombination.

Nucleic acids research - 7 Apr 2016

Gilhooly Neville S, Carrasco Carolina, Gollnick Benjamin, Wilkinson Martin, Wigley Dale B, Moreno-Herrero Fernando, Dillingham Mark S

Abstract excerpt

In bacteria, the repair of double-stranded DNA breaks is modulated by Chi sequences. These are recognised by helicase-nuclease complexes that process DNA ends for homologous recombination. Chi activates recombination by changing the biochemical properties of the helicase-nuclease, transforming it from a destructive exonuclease into a recombination-promoting repair enzyme. This transition is thought to be...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Breaks, Double-Stranded

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Source

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Identifiers

PMID: 26762979
DOI: 10.1093/nar/gkv1543
PMCID: PMC4824097

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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