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Article

Insights into Chi recognition from the structure of an AddAB-type helicase-nuclease complex.

The EMBO journal - 21 Mar 2012

Saikrishnan Kayarat, Yeeles Joseph T, Gilhooly Neville S, Krajewski Wojciech W, Dillingham Mark S, Wigley Dale B

Abstract excerpt

In bacterial cells, processing of double-stranded DNA breaks for repair by homologous recombination is dependent upon the recombination hotspot sequence Chi and is catalysed by either an AddAB- or RecBCD-type helicase-nuclease. Here, we report the crystal structure of AddAB bound to DNA. The structure allows identification of a putative Chi-recognition site in an inactivated helicase domain of the AddB subunit....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22307084
DOI: 10.1038/emboj.2012.9
PMCID: PMC3321194

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Insights into Chi recognition from the structure of an AddAB-type helicase-nuclease complex.PMID 22307084Read ↗

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