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Article

Should individual PI3 kinase isoforms be targeted in cancer?

Current opinion in cell biology - 1 Apr 2009

Jia Shidong, Roberts Thomas M, Zhao Jean J

Abstract excerpt

Activation of the phosphoinositide-3-kinase (PI3K) signaling pathway is frequently found in common human cancers, brought about by oncogenic receptor tyrosine kinases (RTKs) acting upstream, PTEN loss, or activating mutations of PI3K itself. Recent studies have delineated distinct but overlapping...

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Share to Intercellular Signaling Peptides and Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19200708
DOI: 10.1016/j.ceb.2008.12.007
PMCID: PMC3142565

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19200708-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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